E2012 has concentration-dependent inhibitory effects on cholesterol biosynthesis in primary culture of rat hepatocytes and HepG2 cells with IC 50 s of 11.0, and 15.1 nM, respectively.
体内研究
In vivo lenticular concentration of E 2012 after 13-week repeated dose with cataract was well above those where inhibition is observed in vitro. E 2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity.
E 2012 - 配置溶液浓度参考
1mg
5mg
10mg
1 mM
2.384 ml
11.919 ml
23.838 ml
5 mM
0.477 ml
2.384 ml
4.768 ml
10 mM
0.238 ml
1.192 ml
2.384 ml
5 mM
0.048 ml
0.238 ml
0.477 ml
最后更新:2024-01-02 23:10:35
E 2012 - 简介
E 2012 是二甲基碳酸丙烯酯的俗称,它是一种有机化合物。以下是对其性质、用途、制法和安全信息的介绍: